{
 "prereg_sha256": "76eeb3cdd58765b1c7a8372a38b390149a16a2406780670442135873681ad190",
 "stages": [
  {
   "stage": "base selection (polymerase geometry)",
   "factor": 1e-05,
   "what": "the polymerase active site alone"
  },
  {
   "stage": "proofreading (3'->5' exonuclease)",
   "factor": 0.01,
   "what": "excises a mismatched base and retries"
  },
  {
   "stage": "mismatch repair (post-replicative)",
   "factor": 0.001,
   "what": "a second machine reads the NEW strand against the OLD"
  }
 ],
 "product": 1.0000000000000002e-10,
 "verdict": "FAILS - the threshold is decorative",
 "within_1_oom": 3,
 "rows": [
  {
   "organism": "Qbeta / RNA phage",
   "mu": 0.0015,
   "genome": 4200.0,
   "nu_max": 666.6666666666666,
   "margin": 0.15873015873015872,
   "within_1_oom": true,
   "source": "Drake 1993; RNA replicase, no proofreading"
  },
  {
   "organism": "Poliovirus (RNA)",
   "mu": 0.0001,
   "genome": 7500.0,
   "nu_max": 10000.0,
   "margin": 1.3333333333333333,
   "within_1_oom": true,
   "source": "RNA virus, no proofreading"
  },
  {
   "organism": "Influenza A (RNA)",
   "mu": 2.3e-05,
   "genome": 13500.0,
   "nu_max": 43478.260869565216,
   "margin": 3.2206119162640903,
   "within_1_oom": true,
   "source": "segmented RNA virus"
  },
  {
   "organism": "SARS-CoV-2 (RNA + nsp14)",
   "mu": 1e-06,
   "genome": 30000.0,
   "nu_max": 1000000.0,
   "margin": 33.333333333333336,
   "within_1_oom": false,
   "source": "the one RNA virus WITH a proofreading exonuclease"
  },
  {
   "organism": "Bacteriophage lambda",
   "mu": 7.7e-08,
   "genome": 48500.0,
   "nu_max": 12987012.987012986,
   "margin": 267.7734636497523,
   "within_1_oom": false,
   "source": "DNA phage"
  },
  {
   "organism": "E. coli",
   "mu": 5.4e-10,
   "genome": 4600000.0,
   "nu_max": 1851851851.851852,
   "margin": 402.5764895330113,
   "within_1_oom": false,
   "source": "Drake's constant, DNA with full repair"
  },
  {
   "organism": "Human (germline)",
   "mu": 1.1e-08,
   "genome": 3100000000.0,
   "nu_max": 90909090.90909092,
   "margin": 0.029325513196480944,
   "within_1_oom": false,
   "source": "per-base per-generation, trio sequencing"
  }
 ],
 "r": 0.7476560895293236
}